|
Evrim Besray ÜNAL
Department of Computational Sciences and Engineering College of Engineering Koç University e-mail: eunal@ku.edu.tr
Education 2007-2011 PhD, Computational Sciences and Engineering Department, Koc University, Istanbul 2004-2006 MSc, Computational Sciences and Engineering Department, Koc University, Istanbul 1999-2004 BSc, Molecular Biology and Genetics Department, Bogazici University, Istanbul 1996-1999 Kultur Fen Lisesi (Kultur Science High School) Istanbul
Research Interests Peptide design, in silico drug design, thermodynamic properties of peptides, protein-protein interactions.
VitAL server: de novo peptide design server for given protein surfaces.
Research Experience Peptide motif search for protein surfaces. Computer aided peptide design for Cre Protein. Project with Dr. Batu Erman, Sabanci University. Fibroblast Growth Factor Receptor 2 and Fibroblast Growth Factor 3 interaction to uncover mutation leading to deafness in childhood. Project with Dr. Arzu Atalay, Ankara University Biotechnology Institute. Computer aided peptide design for target proteins: · Fibroblast Growth Factor Receptor 2 Protein. Cancer Drug Technologies Project (www.kaniltek.org) funded by Turkish Republic Prime Ministry, State Planning Organization. · Human Growth Hormone and Erythropoietin proteins. Project with Dr. Pinar Calik. Industrial Biotechnology & Metabolic Engineering Research Group, Middle East Technical University, Turkey. · Cryptochrome 2 and Period proteins. Project withDr. I. Halil Kavakli, Koc University. · Nuclear Factor kappaB Protein. Project with Dr. Batu Erman, Sabanci University. Thermodynamic studies on peptide design. 1-28 Amyloid Beta-Peptide interaction with New Drugs / Project for Dalhousie University and University Paris 13 2004 - 2006 Computational search of the Interaction between Melanopsin & Cryptochrome2 proteins in human / MS Thesis 2003 Fall Computational engineering of blood proteins / Bogazici University 1997 - 1998 The Effect of Melatonin Hormone on Male Rat Reproductive Organs / Kultur Science High School
Publications in Refereed Journals 1. Natali Ozber, Ibrahim Baris, Gulnaz Tatlici, Ibrahim Gur, Seda Kilinc, E. Besray Unal, I. Halil Kavakli "Identification of two Amino Acids in the C-terminal Domain of Mouse CRY2 Essential for PER2 Interaction" BMC Mol. Biol., vol. 11, 2010 2. E. Besray Unal, Attila Gursoy, Burak Erman "Viterbi Algorithm for de novo peptide design" PLoS ONE, 5(6): e10926, 2010 3. E. Besray Unal, Attila Gursoy, Burak Erman "Conformational energies and entropies of peptides. Dependence on sequence type, and relation to peptide-protein binding" Phys. Biol., vol. 6, pp. 036014, 2009 4. E. Besray Unal*, Bahar Inankur*, Pınar Çalık, Burak Erman "Computational Analysis of Experimentally Determined Human Growth Hormone Peptide Binders" Conference Proceedings 1. E. Besray Unal, Attila Gursoy, Burak Erman "Inhibitor Peptide Design for NF-kappaB: Markov Model and Genetic Algorithm Approaches" IEEE XPlore, HIBIT'10, 2010 2. E. Besray Unal, Burak Erman, I.Halil Kavakli "Computational Search of the Interaction between Melanopsin and Cryptochrome2 Proteins" FEBS J., vol. 273, pp.43, 2006 3. Mustafa A. Asansu, Mert Poyraz, Mehmet Soner, E. Besray Unal "Effect of Melatonin Hormone on Male Rat Reproductive Organs" Proceedings of 7th Modern Egitim Fen Science Competition, 1998
Presentations Oral Presentations: 1. E. Besray Unal, Attila Gursoy, Burak Erman "Inhibitor Peptide Design for NF-kappaB: Markov Model and Genetic Algorithm Approaches" HIBIT'10, April 2010, Antalya, Turkey 2. E. Besray Unal, Burak Erman, I.Halil Kavakli "Computational Search of the Interaction between Melanopsin and Cryptochrome2 Proteins" 31st FEBS Congress, June 2006, Istanbul, Turkey Poster Presentations: 3. E. Besray Unal, Attila Gursoy, Burak Erman "VitAL Web Server: Viterbi Algorithm for de novo peptide design" HIBIT'11, May 2011, İzmir, Turkey 4. E. Besray Unal, Attila Gursoy, Burak Erman "Conformational energies and entropies of peptides. Dependence on sequence type, and relation to peptide-protein binding" ISMB ECCB 2009, Stockholm, Sweden 5. E. Besray Unal, Attila Gursoy, Burak Erman "Inhibitor Peptide Design Against Fibroblast Growth Factor Receptor 2" Isolated Biomolecules and Biomolecular Interactions IBBI 2008: Theory and Experiment Conference, April 2008, Valladolid, Spain 6. E. Besray Unal, Burak Erman, I.Halil Kavakli "Computational Search of the Interaction between Melanopsin and Cryptochrome2 Proteins," Isolated Biomolecules and Biomolecular Interactions IBBI 2006: Theory and Experiment conference, May 2006, Trest Castle, Czech Republic
7. E. Besray Unal, Burak Erman, I.Halil Kavakli "Computational Search of the Interaction between Melanopsin and Cryptochrome2 Proteins," Emerging Topics in Human Functional Genomics and Proteomics - ICGEB Workshop, March 2006, Antalya, Turkey 8. Mustafa A. Asansu, Mert Poyraz, Mehmet Soner, E. Besray Unal "Effect of Melatonin Hormone on Male Rat Reproductive Organs," 7th Modern Egitim Fen (MEF) Science Competition, May 1998, Istanbul, Turkey
Memberships ISMB, IEEE
Links Halil Kavaklı - Research Group Bogazici University Molecular Biology and Genetics Department Personal Activities Playing Piano, Lindy Hop dancing, Tango, Yoga, Oil Painting
The greatest enemy of knowledge is not ignorance; it is the illusion of knowledge. - S. W. Hawking |
